A lab study examining hundreds of ingredients has demonstrated that resveratrol could help improve the human immune system, and may also enhance the effect of vitamin D.

In an analysis of 446 compounds, researchers in the Linus Pauling Institute at Oregon State University discovered just two that stood out from the crowd for their the ability to boost the innate immune system in humans —the resveratrol found in red grapes and a compound called pterostilbene from blueberries.

Both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function.

The findings were made in laboratory cell cultures and do not prove that similar results would occur as a result of dietary intake, the scientists said, but do add more interest to the potential of some foods to improve the immune response.

The research was published in Molecular Nutrition and Food Research, in studies supported by the National Institutes of Health.

“Out of a study of hundreds of compounds, just these two popped right out,” said Adrian Gombart, an LPI principal investigator and associate professor in the OSU College of Science. “Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It’s a pretty interesting interaction.”

Resveratrol has been the subject of dozens of studies for a range of possible benefits, from improving cardiovascular health to reducing inflammation. This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, scientists said.

The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the “innate” immune system, or the body’s first line of defence and ability to combat bacterial infection. The innate immune response is especially important as many antibiotics increasingly lose their effectiveness.

A strong link has been established between adequate vitamin D levels and the function of the CAMP gene, and the new research suggests that certain other compounds may play a role as well.

Stilbenoids are compounds produced by plants to fight infections, and in human biology appear to affect some of the signalling pathways that allow vitamin D to do its job, researchers said. It appears that combining these compounds with vitamin D has considerably more biological impact than any of them would separately.

Continued research could lead to a better understanding of how diet and nutrition affect immune function, and possibly lead to the development of therapeutically useful natural compounds that could boost the innate immune response, said the researchers in their report.

Despite the interest in compounds such as resveratrol and pterostilbene, their bioavailability remains a question. Some applications that may evolve could be with topical use to improve barrier defence in wounds or infections, they said.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function. The unique biological pathways involved are found in only two groups of animals – humans and non-human primates. Their importance in the immune response could be one reason those pathways have survived through millions of years of separate evolution of these species.


This research shows two things that are relevant to About Health customers, firstly that certain supplements can work together, and secondly that two of the three ingredients in this are major ingredients in two of our products (if you needed a reason to take both of our biggest selling supplements) – Res-V (resveratrol) and Lester’s Oil (Vitamin D).

Reference: http://www.nutraingredients.com/Research/Resveratrol-and-pterostilbene-may-offer-immune-function-benefits-Study/


  1. Lloyd Derbyshire Reply

    Again reflecting my personal experience. After reading my free copy (thx Daniel) of Ian Wishart’s book: ‘Vitamin D: Is this the Miracle Vitamin?’ a few months back I’ve added several thousand extra IUs of D3 to my base daily intake from Lestors Oil and have been feeling healthier as a consequence. Apparently the benefits are amplified because of the interaction with the 2 tablets of Res-V ultimate I take every day too. This is great research and thx for passing it on.

  2. I find this most helpful also as I need a lot of Vitamin D and Calcium to help fight osteoporosis. I take Lesters Oil twice daily and 1 x Res-V daily. Along with that I take 6000IU of Vit D and of course extra calcium. Interesting and very readable.

    • Hi Marilyn, I see that you take extra Vit D. Is that on prescription in NZ or do you source that outside of NZ? Just that I too take large amounts of Vit D but have to source it from outside NZ

  3. Hi interesting my husband and I have not had colds or flu since 1998 and we are both in our seventies. Can’t risk NOT taking Res V. We both feel great and are very active and also we are very healthy. We have also moved on to take Lesters Oil. I think at our age if you are healthy and active you are lucky. Off to Thailand soon and our pills will be coming with us.

  4. We love all your products.
    You give us the best so we have little more to add.
    Thank you.

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